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Table 2 Patient characteristics stratified by magnesium level in SOC Cohort

From: Hypomagnesemia in lymphoma patients receiving CAR T therapy correlates with immune dysfunction and decreased survival

 

Low Mg (< 1.7 mg/dL)

N = 12

Normal Mg (1.7 – < 2.0 mg/dL)

N = 30

High Mg

(≥ 2.0)

N = 15

Total

N = 57

P value

Age

Median (Q1, Q3)

61 (55, 65)

57 (41, 62)

60 (54, 64)

59 (44–64)

0.20

 Range

38–75

27–77

27–77

27–77

 

Male sex

6 (50%)

18 (60%)

10 (67%)

34 (60%)

0.67

Caucasian race

8 (67%)

26 (87%)

13 (87%)

47 (82%)

0.33

Diagnosis

     

 DLBCL

5 (42%)

22 (73%)

9 (60%)

36 (63%)

0.14

 HG

4 (33%)

2 (7%)

1 (7%)

7 (12%)

 

 PMBCL

0 (0%)

0 (0%)

1 (7%)

1 (2%)

 

 TFL

3 (25%)

6 (20%)

4 (27%)

13 (23%)

 

ECOG PS ≥ 1

6 (50%)

11 (37%)

6 (40%)

23 (40%)

0.72

Elevated LDH (> 220 U/L), no (%)

9 (75%)

19 (63%)

10 (67%)

38 (67%)

0.87

IPI ≥ 3, number (%)

9 (75%)

13 (43%)

9 (60%)

31 (54%)

0.18

Stage III/IV Yes (%)

12 (100%)

27 (90%)

15 (100%)

54 (95%)

0.41

Extranodal disease

11 (92%)

16 (53%)

10 (67%)

37 (65%)

0.07

Prior lines of therapy

 Median (Q1, Q3)

3.5 (3, 4)

3 (3, 4)

3.0 (2–4)

3.0 (3, 4)

0.25

 Range

3–5

1–6

2–5

1–6

 

Prior ASCT

6 (50%)

14 (47%)

5 (33%)

25 (44%)

0.68

  1. Mg: magnesium; DLBCL: diffuse large B cell lymphoma; HG high-grade lymphoma; PMBCL: primary mediastinal large B cell lymphoma; TFL transformed follicular lymphoma; ASCT: autologous stem cell transplant; ECOG PS: eastern cooperative oncology group performance status; LDH lactate dehydrogenase; IPI: international prognostic index; LD: chemo lymphodepleting chemotherapy