Fig. 2

Pathological refinement in 788 STS samples via integrated histology and molecular genetics illustrated schematically. (A) Flow chart of corrections of initial pathological diagnosis results in the sarcoma cohort. (B) and (C) Sankey diagram illustrating the diagnostic changes in pathological definite group of 595 samples and unclassified sarcomas group of 43 samples (B) and not specified group of 150 samples (C). Bar chart, proportion of pathological refinements for each sarcoma subtype after initial diagnosis; Sankey diagrams: Left nodes, number of cases identified for each subtype according to initial submitted pathology results; Middle nodes, the specific forms and number of histology-specific fusions; right nodes, number of corrections or refinements for each histology as determined by the presence or absence of pathognomonic genomic rearrangements or signatures